When do you know all hope is lost?

My wife of 6 years told me the other night that she doesn't like me touching her and was repulsed when I kissed her previously during sex. If we were dating, well that would be the end of it! I've tried to soldier on and she is behaving as though nothing has changed. Our marriage has been rocky from the beginning due to her suffering from depression. Her ant- depressants she is on ( and has been most of her life) affect her sex drive and moods. If it wasn't for our 4 year old daughter I think I would call it quits. I am lost. Any advice out there?

You have a lot to think about. But let me give you another perspective. I was a child from a marriage where the parents were unhappy. Before my parents got divorced they weren't even sleeping in the same bedroom. I was a child but I knew how unhappy and how miserable they were. And a lot of the time I felt alone, isolated and wondered if I was doing something wrong. I felt like their misery was my fault because I knew they were staying together because of me. To see my parents unhappy and to feel that way for years and years, from as long as I can remember till I was 15 has affected me so negatively in my present. I have chosen abusive men because all I saw was an unhappy husband and partner. I didn't know what a good relationship was. My relationships with men suffer because I'm full of doubt, I have made such bad choices. I went through my own depression and mental problems as a teen when I grew up and understood even better the state of my parents marriage. It's such a big thing to decide if you want to keep fighting and I'm sorry you feel so lost. Try couples counseling, try alternatives to the antidepressant drugs. If you think there is a chance for you to save your marriage and be HAPPY then fight for it. I know every marriage has points where you think it's going to break. But really think about what's best for your mental state and your daughters.

ask her if she loves you,and decide as for the child she wants a loving family