Motivation / self esteem

Hi guys. Ive always had a problem talking out my problems with people face to face, so I thought i'd try this forum in the hope that someone can help me figure out whats going on. For quite a long time i've had motivational issues, and from time to time by self esteem has dipped a little, but at present I seem to have broken new ground. I am in my 1st year at Uni, and moved into halls last October. Living on my own for the 1st time has left me feeling isolated, but it has also made me realise that i've felt this way for longer. I wouldn't regard any of my new classmates as friends, and in all honesty, I feel a little outcast from the rest and I don't know why. Only now have I realised that this is not a new trend. Throughout my teenage years I had so called 'friends' at school, but I would never be invited out with them after school or during weekends. Eventually I found a group who did, but I have lost contact with most of them after leaving school. I went to College, and thought I had made some good friends there, but for some reason, I was suddenly shunned when we came back for our 2nd year. At present, I make an effort to get to know people, but whenever I try to organise a social occasion, whether it be with 1 or 10 people, I get no replies. Even my school friend who wanted to start up a Funk band doesn't reply to my messages. Every time I try to do something with myself, it feels like everyone else is hell-bent on stopping me. This has made me feel alienated, misfit and leaves me with no motivation to get up, go to Uni, or much else. All I do these days is keep myself company in the flat, and try to make sense of all the negative things i'm feeling. Naturally, this just makes me feel worse as the only conclusion I can draw is that I am unliked my most, and I have thus far failed to find the reason. Has anyone else experienced similar problems? If so, how do you deal with this?